Objectives: To investigate the insulin sensitivity in normotensive offspring of hypertensive
parents. Subjects: Fifteen young normotensive offspring of hypertensive parents were paired with 15
controls matched for age, sex and body mass index. Methods: The insulin sensitivity was investigated by 75 g oral glucose tolerance test (OGTT)
and modified insulin suppression test. A high-fat mixed meal was administered to observe
the changes of TG levels. Results: The plasma glucose and serum insulin responses to oral glucose challenge were comparable
between both groups. High-fat mixed meal made no difference in the plasma glucose,
serum triglyceride or insulin between the 2 groups. With the modified insulin suppression
test, the steady-state plasma glucose levels (SSPG) were higher in the offspring of
parents with essential hypertension (138 ± 43 mg/dl) than in the control group (95
± 26 mg/dl). The diastolic blood pressure and heart rate of the offspring of hypertensive
parents are also higher than the control group. Conclusions: Insulin resistance exists in young normotensive offspring of hypertensive parents,
and the impairment of insulin-mediated glucose uptake in these subjects develop before
any alteration of fasting and postprandial triglyceride.
Key words
Essential Hypertension - Insulin-Mediated Glucose Uptake - Hypertriglyceridemia
